D-amino acid in irradiated and aged mouse.

Mouse d-Amino-Acid Oxidase: Distribution and Physiological Substrates

d-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of d-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological substrates of mouse DAO. Mouse DAO is present in the kidney, brain, and spinal cord, like DAOs in other mammals. However, in contrast to other animals, it is not present in the mouse liver. Rece...

Mouse mutant deficient in D-amino acid oxidase activity.

D-Amino acid oxidase activity in the kidney homogenates of mice of seven strains was measured to search for a mutant for this enzyme. There was a consistent sex difference in the enzyme activity in these strains: male mice showed higher levels of the enzyme activity than females. In contrast to other strains, some mice of the ddY strain did not possess enzyme activity. This trait was inheritabl...

Protein synthesis and amino acid pools in irradiated yeast cells.

Protein synthesis after UV- and X-irradiation was investigated in diploid yeast. The incorporation of radioactively labelled lysine and phenylalanine was measured 2.5 and 4 hours after exposure. By varying the specific activity the pool sizes could be estimated. At 2.5 hours there is some increase in pool sizes and a dose-dependent enhancement of protein synthesis. At 4 hours pools are again no...

Spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase during mouse postnatal development.

AIM To elucidate the spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase (EC 1.4.3.3; DAO) in mouse cortex, striatum, cerebellum, heart, lung, liver, spleen, kidney, and skeletal muscle during mouse postnatal development. METHODS The transcription levels of serine racemase and DAO were assayed by reverse transcription-polymerase chain reaction (RT-PCR). The ...

Astudyon D-amino-acid Oxidase